Annotation Overview for fig|259564.8.peg.1603 in Methanococcoides burtonii DSM 6242:
L-Aspartate dehydrogenase (EC 1.4.1.21)

current assignment	L-Aspartate dehydrogenase (EC 1.4.1.21)	EC Number	1.4.1.21
taxonomy id	259564	contig	259564.8:NC_007955 (2,575,033bp)
internal links	genome browser | feature evidence | sequence	ACH Annotation Clearinghouse (ACH) The Annotation Clearinghouse offers a mapping of genes which are identical in sequence except for the start region (due to differences in start calling). [?]	show essentially identical genes
annotation history		run tool	Psi-BlastTMpredTMHMMGram negative PSORTGram negative SignalPGram positive PSORTGram positive SignalPLipoPInterProScanRadarPPSearchGram negative CELLOGram positive CELLOProDomPDB
FigFam	FIG063566
data base cross references (dbxref)	RefSeq: YP_566325.1 UniProt: Q12VF1 NCBI: 91712648 UniProt: Q12VF1_METBU NCBI: 91773633 CMR: NTL03MB1658

Annotation History (history of similar genes)

Date	Annotator	Annotation
11/30/2004	RossO	Set FIG function to putative dinucleotide-utilizing enzyme
3/13/2005	AndreiO	Set FIG function to Aspartate dehydrogenase [same functional role as] (EC 1.4.3.16)
3/13/2005	AndreiO	Set FIG function to Predicted dinucleotide-utilizing enzyme
3/17/2005	AndreiO	Set FIG function to COG1712: Predicted dinucleotide-utilizing enzyme
3/17/2005	AndreiO	Set FIG function to Aspartate dehydrogenase [same functional role as] (EC 1.4.3.16)
4/10/2005	AndreiO	Set FIG function to COG1712: Predicted dinucleotide-utilizing enzyme
8/30/2005	annotation_repair	Annotation for existing assignment Aspartate dehydrogenase [same functional role as] (EC 1.4.3.16) that did not match latest annotation COG1712: Predicted dinucleotide-utilizing enzyme
8/30/2005	annotation_repair	Set FIG function to Aspartate dehydrogenase [same functional role as] (EC 1.4.3.16)
4/9/2007	leoS	Set FIG function to L-Aspartate dehydrogenase (EC 1.4.1.21)
9/24/2007	rapid_propogation	Set function to aspartate dehydrogenase from original annotations
9/24/2007	rapid_propogation	Set function to L-Aspartate dehydrogenase (EC 1.4.1.21) based on FIGfams
11/1/2007	salvage	Old and new assignments are the same L-Aspartate dehydrogenase (EC 1.4.1.21)

We have assigned the function "L-Aspartate dehydrogenase (EC 1.4.1.21)" to the encoded protein. The protein occurs in 1 subsystem: "NAD and NADP cofactor biosynthesis global". In "NAD and NADP cofactor biosynthesis global", it appears to play a functional role that we have not associated with any other gene. The function of genes having the same functional roles have been described in Thermotoga maritima (12496312). This is a homologous protein which implements the same function.

The chromosomal region of the focus gene (top) is compared with four similar organisms. The graphic is centered on the focus gene, which is red and numbered 1. Sets of genes with similar sequence are grouped with the same number and color. Genes whose relative position is conserved in at least four other species are functionally coupled and share gray background boxes. The size of the region and the number of genomes may be reset. Click on any arrow in the display to refocus the comparison on that gene. The focus gene always points to the right, even if it is located on the minus strand.